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Health Canada: February 27, 2008

Further to its information update dated August 9, 2007, Health Canada is informing Canadians of the results of its review of safety information for Losec (omeprazole) and Nexium (esomeprazole), two prescription drugs used to treat conditions where a reduction of gastric acid secretion is required, such as ulcers and reflux. In Canada, omeprazole is also sold in generic form as Apo-omeprazole, Ratio-omeprazole and Sandoz-omeprazole. Esomeprazole is only sold under the trade name Nexium.

Nexium (esomeprazole)
Based on its review of the data available at this time, Health Canada has concluded that there is no evidence supporting an increased cardiovascular risk associated with the long-term use of esomeprazole.

The Department will continue to monitor safety issues related to esomeprazole by conducting further analysis of ongoing long-term studies as this data becomes available.

In light of this information, patients taking omeprazole or esomeprazole should not make any changes to their medication unless discussed with their doctor, as ulcers and reflux can lead to other complications if left untreated.

Consumers requiring more information about this advisory can contact Health Canada's public enquiries line at (613) 957-2991, or toll free at 1-866-225-0709

What is Nexium (esomeprazole)?

NEXIUM is a type of medicine known as an acid pump inhibitor (also known as a proton pump inhibitor, or PPI). The lining of your stomach contains millions of special cells that produce acid via "acid pumps." It is the job of these pumps to produce the acid that helps in the digestion of food.

NEXIUM works by decreasing the acid produced by these acid pumps. NEXIUM turns off (deactivates) some of the pumps to keep acid production under control. By reducing acid production in the stomach, buy NEXIUM reduces the amount of acid backing up into the esophagus and causing reflux symptoms. But don't worry, you still have enough acid to take care of digestion.

Prolonged acid reflux can, over time, slowly wear away or erode the delicate lining of your esophagus. Only a doctor can determine if you have this damage. buy NEXIUM can help heal this damage. In clinical tests, up to 94% of patients were healed with NEXIUM.

The lining of your stomach contains millions of special cells that produce acid via "acid pumps." It is the job of these pumps to produce the acid to help digest food. For people with acid reflux disease (GERD) this acid backs up into the esophagus where it doesn't belong. buy NEXIUM works by deactivating (turning off) some of the pumps. By reducing acid production in the stomach, NEXIUM reduces the chance of acid backing up into the esophagus and causing heartburn symptoms.

For many people, NEXIUM has been shown to provide complete, sustained relief from frequent, persistent heartburn. That's 24-hour round-the-clock heartburn relief, even after meals, from just one NEXIUM a day. And that's another good reason to see your doctor about NEXIUM. Your results may vary.

You may not know this, but prolonged acid reflux can, over time, slowly wear away or erode the delicate lining of your esophagus. buy NEXIUM has been proven to heal these damaging erosions. In fact, in clinical tests, nearly 9 out of 10 patients with acid reflux-related erosions were successfully treated with NEXIUM.

How to Use Nexium

Taking NEXIUM should be part of your usual routine so that you do not forget to take it. buy NEXIUM capsules should be taken at least one hour before meals and at the same time every day. The capsules should also be swallowed whole, never chewed or crushed. If you have a hard time swallowing capsules, you can empty a capsule into a tablespoon of applesauce. The applesauce should be eaten right away and never stored for later use. The pellets should not be chewed or crushed.

Do not use buy NEXIUM to treat any other medical conditions unless instructed by your doctor. Never share NEXIUM with anyone else - it has been prescribed for you!

Nexium Possible Side Effects

NEXIUM can cause side effects. The most common side effects are:

Headache
Abdominal Pain
Diarrhea
How does buy NEXIUM interact with other medications I am taking?

We cannot predict what will happen to any particular individual. Drug interactions can occur in individual patients receiving concurrent medications. When any drug is prescribed, the possibility of drug interactions should always be considered.

Remember to list all the medications that you are taking and include those that you take without a prescription.

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