A brief comparison by some of the physicians on the effective use of Didrex drug for reducing weight and managing obesity reveals that while some studies accept the results as encouraging and beneficial, there are other findings which contradict these results and note that Didrex was beneficial on reducing weight or managing obesity. In addition, studies which showed the findings to be beneficial also noted that they were only helpful for a limited time, and that the weight was rapidly regained after the drug was discontinued.

There was however a significant set of evidence which showed that there were drugs or a combination of drugs which showed their effectiveness in both the promotion as well as the maintenance of long term weight loss. For example, Phentermine in combination with fenfluramine or dexfexfluramine offered some of the best scope for long term management of weight loss.

Thus, category of patients who benefited the most from the use of phentermine in combination with either fenfluramine or dexfexfluramine included those already on a diet program, exercise and behavioral modification. However, the usage of drugs proved beneficial when they were administered in chronicle order.

Yet, another set of factors which limits the use of anorectic drugs are its side effects, the cost as well the tendency for potential abuse. It is these set of reasons which force physicians and doctors to advise patients on the careful intake of such drugs, as well as continuous monitoring of various changes in the body including the blood pressure, the heart rate as well as the aggravation of undiagnosed cardiac problems.

In this context, both the consulting physicians as well as obese patients must understand that obesity is a chronic disease similar to diabetes mellitus and hypertension, and thus the need for requisite management of obesity through out the life span of the respective individual must note it.